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Type I phosphomannose isomerases (PMIs) are zinc‐dependent metalloenzymes involved in the reversible isomerization of D‐mannose 6‐phosphate (M6P) and D‐fructose 6‐phosphate (F6P). 5‐Phospho‐D‐arabinonohydroxamic acid (5PAH), an inhibitor endowed with nanomolar affinity for yeast (Type I) and Pseudomonas aeruginosa (Type II) PMIs (Roux et al., Biochemistry 2004; 43:2926–2934), strongly inhibits human...
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