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This letter describes the further exploration of two series of M 1 allosteric agonists, TBPB and VU0357017, previously reported from our lab. Within the TPBP scaffold, either electronic or steric perturbations to the central piperidine ring led to a loss of selective M 1 allosteric agonism and afforded pan-mAChR antagonism, which was demonstrated to be mediated via the orthosteric...
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