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Axis inhibition proteins 1 and 2 (Axin1 and Axin2) are scaffolding proteins that modulate at least two signaling pathways that are crucial in skeletogenesis: the Wnt/β‐catenin and TGF‐β signaling pathways. To determine whether Axin2 is important in skeletogenesis, we examined the skeletal phenotype of Axin2‐null mice in a wild‐type or Axin1+/− background. Animals with disrupted Axin2 expression displayed...
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