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Blood–Brain Barrier
In article number 2106860, Kangwon Lee, Nakwon Choi, Hong Nam Kim, and co‐workers fabricate a brain‐on‐a‐chip platform to replicate the complicated glioblastoma multiforme microenvironment and the anatomical features and functionality of the in vivo blood–brain barrier, and demonstrate the influence of the glioblastoma multiforme microenvironment on tumor behavior and drug delivery...
Physiologically, brain tumors interact with surrounding vascular and glial cells, and change their responses to survive in brain tissue‐specific microenvironments. A major difficulty in brain tumor treatment is caused by the organism's high resistance to pharmaceutical drugs and poor blood–brain barrier (BBB) penetration. Therefore, mimicking the physiological environment of brain tumors on in vitro...
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