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Membrane type 1 matrix metalloproteinase (MT1‐MMP) binds to and regulates the function of tetraspanin‐enriched microdomains. It also physically interacts with claudin‐1 and acireductone dioxygenase 1 (ADI1), both associated with hepatitis C virus (HCV) cell entry. Here, we examined hepatic expression of MT1‐MMP, ADI1 and claudin‐1 as well as their physical interaction in relation to serum or intrahepatic...
Summary. Antiviral effect of interferon is mediated by the expression of interferon‐stimulated genes (ISGs). However, because of the difficulty in obtaining paired liver biopsies before and after interferon treatment, the key ISGs expressed in human hepatocytes and responsible for interferon‐based antiviral activities in chronic hepatitis C remain illusive. Prior to a standard course of peginterferon...
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