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Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9mg/kg BW for 6weeks. All...
Scope Xanthohumol (XN), a dietary flavonoid found in hops, may have health‐protective actions against cardiovascular disease and type 2 diabetes. Yet, there are limited data on the pharmacokinetics (PK) of XN. This study provides PK parameters for XN and its major metabolites in rats.
Methods and results A PK study was conducted in male jugular vein‐cannulated Sprague‐Dawley rats. Rats (n = 12/group)...
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