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Locating nanotherapeutics at the active sites, especially in the subcellular scale, is of great importance for nanoparticle‐based photodynamic therapy (PDT) and other nanotherapies. However, subcellular targeting agents are generally nonspecific, despite the fact that the accumulation of a nanoformulation at active organelles leads to better therapeutic efficacy. A PDT nanoformulation is herein designed...
Singlet oxygen (1O2), as an important kind of reactive oxygen species (ROS) and main therapeutic agent in photodynamic therapy (PDT), only have a half‐life of 40 ns and an effective radius of 20 nm, which cause significant obstacles for improving PDT efficacy. In this work, novel upconversion nanoparticle (UCN)‐based nanoplatforms are developed with a minimized distance between UCNs and a photosensitizer,...
In article number 1602053, Ke Tao, Guangdong Zhou, Kang Sun and co‐workers novel nanoplatforms for photodynamic therapy (PDT) are developed. By targeting the reactive oxygen species (ROS) producing nanoplatform at mitochondria sites a more significant enhancement of the photodynamic therapy efficacy is demonstated. The findings may provide a novel strategy for designing nanomedicines for PDT.
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