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Front Cover: A bottom‐up supramolecular approach capitalizing on the biotin‐avidin interaction was used to fabricate supramolecular fusion toxins. The method not only allow the precise assembly with modular features but also redirect the cell entry of a native toxin and circumvent its low uptake into epithelial cell lines. Further details can be found by Seah Ling Kuan, Christina Förtsch, David Yuen...
Nature has provided a highly optimized toolbox in bacterial endotoxins with precise functions dictated by their clear structural division. Inspired by this streamlined design, a supramolecular approach capitalizing on the strong biomolecular (streptavidin (SA))–biotin interactions is reported herein to prepare two multipartite fusion constructs, which involves the generation 2.0 (D2) or generation...
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