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In this report, we applied in situ atomic force microscopy (AFM) to study the dynamic process of disassembly–assembly of α-synuclein (α-Syn) fibrils in different solutions. Most of the mica-adsorbed α-Syn fibrils disassemble into small particles step-by-step on the mica surface in diluted solutions, yet a few short fibrils still extend to form longer fibrils. This process usually started randomly...
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