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A multiscale model of blood clot (thrombus) formation is extended by adding a sub-model of the tissue factor (TF) pathway of blood coagulation to provide more biologically relevant description of coagulation process. A combination of experimental approach, image analysis and a multiscale modeling is used for studying role of factor VII and fibrin in limiting growth of a blood clot. The simulations...
In this paper, we study the problem of segmenting, reconstructing, and analyzing the structure and growth of thrombi (clots) in vivo in blood vessels based on 2-photon microscopic image data. First, we develop an algorithm for segmenting clots in 3-D microscopic images which incorporates the density-based clustering algorithm and other methods for dealing with imaging artifacts. Next, we apply the...
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