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Continuous exposure of breast cancer cells to adriamycin induces high expression of P-gp and multiple drug resistance. However, the biochemical process and the underlying mechanisms for the gradually induced resistance are not clear. To explore the underlying mechanism and evaluate the anti-tumor effect and resistance of adriamycin, the drug-sensitive MCF-7S and the drug-resistant MCF-7Adr breast...
Metabolomics allows high-throughput analysis of low-molecular-weight compounds in biofluids that reflect the physiological status and biochemical metabolism of living systems. Hence it has the potential to evaluate toxicity and clarifies the metabolism-related toxic mechanisms. In this study a promising candidate drug parent, triptolide, was given to Sprague–Dawley rats as a model toxicant at a single...
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