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BRCTs are phosphoserine‐binding domains found in proteins involved in DNA repair, DNA damage response and cell cycle regulation. BRCA1 is a BRCT domain‐containing, tumor‐suppressing protein expressed in the cells of breast and other human tissues. Mutations in BRCA1 have been found in ca. 50 % of hereditary breast cancers. Cell‐permeable, small‐molecule BRCA1 inhibitors are promising anticancer agents,...
Schnell und effizient: Eine Bibliothek trans‐Cycloocten(TCO)‐modifizierter kleiner Moleküle wurde mit der schnellsten bekannten bioorthogonalen Reaktion auf Tetrazin‐funktionalisierten Glasträgern immobilisiert. Der erhaltene Mikroarray wurde gegen eine Vielzahl humaner Bromodomänen getestet, um Inhibitoren von Protein‐Protein‐Wechselwirkungen zu identifizieren.
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