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The application of biotransformations in solid phase synthesis is an attractive alternative to chemical methodologies. An important issue that needs to be addressed in this context is accessibility of functional groups within a porous polymer to the biocatalyst. This paper shows that such accessibility can be improved for penicillin G amidase by introducing permanent charges into the polymer. The...
Organically modified xerogels (OMX NH2 ) can be used as an easy to handle and chemically stable support in solid-phase chemistry and are compatible with enzymatic transformations.
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