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BACKGROUND
Low serum testosterone (low T) has been repeatedly linked to worse outcomes in men with newly diagnosed prostate cancer (PC). How low T contributes to these outcomes is unknown. Here we demonstrate that exposure to low T causes significant changes in the mouse prostate and prostate stem cells.
METHODS
Mice were castrated and implanted with capsules to achieve castrate, normal, or sub‐physiological...
In this study, we aimed to determine the feasibility of identifying CTCs in patients with HRLPC, using a modified isolation procedure using the CellSearch (Veridex) platform, and to assess the expression of stem cell and epithelial-mesenchymal transition (EMT) markers on the CTCs.Thirty-five patients with HRLPC who had chosen prostatectomy for definitive management were prospectively identified. After...
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