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Objective: Although lipid crystals (LCs) have received attention as a causative factor of plaque rupture, the mechanisms by which they increase plaque vulnerability are unknown. We examined whether solid-state LCs physically affect the adjacent extracellular matrix (ECM) using a combination of multimodal nonlinear optical (MNLO) imaging and finite element analysis (FEA). Methods: The changes of ECMs...
Purpose & Methods: In order to analyze the incidence and characteristics of the mutation of low density lipoprotein receptor (LDL-R) gene in Korean familial hypercholesterolemia (FH) patients, we screened large as well as point mutation of LDL-R gene in total 37 probands who showed the familial tendency of hypercholesterolemia higher than 280 mg/dl with Achilles tendon thicker than 9 mm and their...
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