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The causation of cancer often involves the joint deregulation of multiple biological processes. Thus, it is interesting to extract multi-function features of cancer genes and study their functional coordination involved in tumorigenesis. Here, based on Gene Ontology, we proposed a heuristics strategy to extract multi-function features which are significantly overrepresented with cancer genes. We showed...
Since diseases might be related with each other, systematically assessing their relationships could provide us novel insight into their mechanisms. One of the most important methods to study diseases' relationships is to calculate their phenotype similarity scores based on the text and clinical synopsis parts of their records in the OMIM database. However, as demonstrated in this paper, the similarity...
Aging is a complex process associated with a number of molecular events at multidimensional levels. Understanding the characteristics of aging is important for elaborating the molecular mechanism of many diseases such as Alzheimer. In this paper, we systematically analyzed topological features of proteins encoded by human aging genes versus those encoded by non-aging genes in protein-protein interaction...
After decades of searching, only 10-20% of all cancer genes are known. Identifying candidate cancer genes are still a central aim of cancer research. In current high throughput studies of screening somatic mutations in cancer genome, only genes mutated more frequently than what would be expected by chance are determined as candidate cancer genes. However, mutations of multiple genes participating...
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