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Fluorescence resonance energy transfer (FRET) is applied to investigate the enzyme‐responsive payload release from a macromolecular therapeutic. The donor Cy5 is attached to the N‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer backbone and the acceptor Cy7 is bound to the termini of enzyme‐sensitive peptide side chains. Upon exposure to an enzyme, the bond between the peptide and Cy7 is cleaved,...
There is a need for new treatment strategies of acute myeloid leukemia (AML). In this study, four different drugs, including cytarabine, daunorubicin, GDC‐0980, and JS‐K, were investigated in vitro for the two‐drug combinations treatment of AML. The results revealed that cytarabine and GDC‐0980 had the strongest synergism. In addition, cell cycle analysis was conducted to investigate the effect of...
This chapter focuses on two new designs of macromolecular therapeutics. First, the design, synthesis, and evaluation of backbone degradable high molecular weight (second generation) water‐soluble polymer–anticancer drug conjugates – are presented. Then, a new paradigm in drug delivery, drug‐free macromolecular therapeutics, is discussed in detail. Finally, future perspectives of the field are briefly...
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