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The regulator of G protein signaling (RGS) proteins modulate heterotrimeric G protein signaling. RGS8 was identified as a brainspecific RGS protein of 180 amino acids. Biochemical studies indicated that RGS8 binds to Gao and Gαi3, and that it functions as a GTPase-activating protein (GAP) for Gα subunits. Physiological investigations demonstrated that RGS8 is not a simple negative regulator, but accelerates...
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