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As conjugated polymer nanoparticles (CPNs) have attracted growing interest as photoacoustic (PA) imaging contrast agents, revelation of the relationship between the molecular structure of conjugated polymers and PA property is highly in demand. Here, three donor–acceptor‐structured conjugated polymer analogs are designed, where only a single heteroatom of acceptor units changes from oxygen to sulfur...
A novel mesoporous nanosheet networked hybrid comprising Co3O4 and Co3(PO4)2 is successfully synthesized using a facile and scalable method through calcinating the carbon, cobalt hydroxy carbonate, and cobalt phosphate composite precursor. Electron transfer from Co3O4 to Co3(PO4)2, together with the special networked structure and the porous nature of the nanosheets enable the Co3(PO4)2‐Co3O4 hybrid...
Near infrared (NIR) light triggered phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) affords superior outcome in cancer treatment. However, the reactive oxygen species (ROS) generated by NIR‐excited upconversion nanostructure is limited by the feeble upconverted light which cannot activate PDT agents efficiently. Here, an IR‐808 dye sensitized upconversion nanoparticle...
A multifunctional theranostic platform based on conjugated polymer nanoparticles (CPNs) with tumor targeting, fluorescence detection, photodynamic therapy (PDT), and photothermal therapy (PTT) is developed for effective cancer imaging and therapy. Two conjugated polymers, poly[9,9‐bis(2‐(2‐(2‐methoxyethoxy)ethoxy)‐ethyl)fluorenyldivinylene]‐alt‐4,7‐(2,1,3‐benzothiadiazole) with bright red emission...
Multifunctional conjugated polymer nanoparticles (CPNs) are developed for image‐guided phototherapy by D. Ding, B. Liu, and co‐workers in article number 1602807. Under proper light irradiation, these CPNs display bright red fluorescence, efficient singlet oxygen generation and excellent photothermal conversion abilities. With affibody decoration, these CPNs show excellent tumor targeting and synergistic...
Stem‐cell based therapy is an emerging therapeutic approach for ischemic stroke treatment. Bone marrow stromal cells (BMSCs) are in common use as a cell source for stem cell therapy and show promising therapeutic outcomes for stroke treatment. One challenge is to develop a reliable tracking strategy to monitor the fate of BMSCs and assess their therapeutic effects in order to improve the success rate...
Long‐term tracking of bone marrow stromal cells in a rat photothrombotic ischemia model is achieved by organic nanoparticles with aggregation‐induced emission. On page 6576, L.‐D. Liao, B. Liu, and co‐workers demonstrate the design and synthesis of the nanoparticles to realize low phototoxicity and high stability. These nanoparticles show promising potential for monitoring the transplanted stem cells...
The combination of diagnosis and therapeutics into one theranostics system has attracted great interest in life science and biomedical fields. The current theranostic platform largely relies on the integration of multiple materials with different functionalities. The all‐in‐one approach has the risk of high complicity with reduced reproducibility. Smart design of simple molecules born with multifunctions...
Conjugated polymers have been increasingly studied for photothermal therapy (PTT) because of their merits including large absorption coefficient, facile tuning of exciton energy dissipation through nonradiative decay, and good therapeutic efficacy. The high photothermal conversion efficiency (PCE) is the key to realize efficient PTT. Herein, a donor–acceptor (D–A) structured porphyrin‐containing conjugated...
Noninvasive and nonionizing imaging of sentinel lymph nodes (SLN) is highly desirable for the detection of breast cancer metastasis through sentinel lymph node biopsy. Photoacoustic (PA) imaging is an emerging imaging technique that can serve as a suitable approach for SLN imaging. Herein, novel conjugated oligomer based nanoparticles (NPs) with strong NIR absorption, good biocompatibility, excellent...
Robust luminescent dyes with efficient two‐photon fluorescence are highly desirable for biological imaging applications, but those suitable for organic dots fabrication are still rare because of aggregation‐caused quenching. In this work, a red fluorescent silole, 2,5‐bis[5‐(dimesitylboranyl)thiophen‐2‐yl]‐1‐methyl‐1,3,4‐triphenylsilole ((MesB)2DTTPS), is synthesized and characterized. (MesB)2DTTPS...
Recent years have witnessed increasing interest in the solution‐phase synthesis of atomically precise thiolate‐protected gold clusters (Aux); nonetheless, research on the photocatalytic properties of Aux–semiconductor nanocomposites is still in its infancy. In this work, recently developed glutathione‐capped gold clusters and highly ordered nanoporous layer‐covered TiO2 nanotube arrays (NP‐TNTAs)...
Glutathione‐capped gold clusters and highly ordered nanoporous layer‐covered TiO2 nanotube arrays (NP‐TNTAs) are employed as nanobuilding blocks for a well‐defined Au/NP‐TNTA heterostructure via electrostatic self‐assembly. On page 554, B. Liu and co‐workers show how tailor‐made Au clusters are evenly distributed on the interior and exterior surfaces of the framework. Versatile photocatalytic performances...
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