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Immune-checkpoint-blockade (ICB)-mediated rejuvenation of exhausted T cells has emerged as a promising approach for treating various cancers and chronic infections. However, T cells that become fully exhausted during prolonged antigen exposure remain refractory to ICB-mediated rejuvenation. We report that blocking de novo DNA methylation in activated CD8 T cells allows them to retain their effector...
A critical component of vaccine design is to generate and maintain antigen‐specific memory lymphocytes of sufficient quantity and quality to give the host life‐long protection against re‐infection. Therefore, it is important to understand how memory T cells acquire the ability for self‐renewal while retaining a potential for heightened recall of effector functions. During acute viral infection or...
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