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The CRF 2 receptor is involved in stress responses, cardiovascular function and gastric motility. Endogenous agonists (urocortin (UCN) 2, UCN 3) and synthetic antagonists (astressin 2 -B, antisauvagine-30) are selective for CRF 2 over the CRF 1 receptor. Peptide ligand binding properties of the CRF 2 receptor require further investigation, including ligand affinity...
Previous corticotropin releasing factor 1 (CRF 1 ) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity states of the CRF 1 receptor heterologously expressed in Ltk ...
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