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The κ-neurotoxins are useful ligands for the pharmacological characterization of nicotinic acetylcholine receptors because they are potent antagonists at only a subgroup of these receptors containing either α3- or α4-subunits (ic 50 ≤ 100 nM). Four of these highly homologous, 66 amino acid peptides have been purified from the venom of Bungarus multicinctus [κ-bungarotoxin (κ-Bgt), κ2-Bgt,...
J. J. Fiordalisi, P. L. James, Y. Zhang and G. A Grant. Facile production of native-like K-bungarotoxin in yeast: an enhanced system for the production of a neuronal nicotinic acetylcholine receptor probe. Toxicon 34, 213-224, 1996.--Research on the mammalian central nervous system has been hindered by the limited number and meager supply of naturally occurring toxins that can be used as pharmacological...
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