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To better address the need for developing stable formulations of plasmid DNA‐based biopharmaceuticals, 37 compounds from a generally regarded as safe library were examined for their potential use as stabilizers. A plasmid DNA‐based therapeutic vaccine, BHT‐DNA™, was used as a model system. Initial studies were performed to compare the biophysical properties of BHT‐DNA™ plasmid from bulk drug substance...
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