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Anthrax lethal factor (LF) is a zinc-dependent metalloendopeptidase and a member of the gluzincin family. The current report demonstrates a high metal substitution tolerance of LF atypical of gluzincins and other zinc-dependent metalloproteases. Mn 2+ , Co 2+ , Ni 2+ , Cu 2+ and Cd 2+ were found to reactivate the apoprotein of LF to a level either comparable...
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