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Metallo-β-lactamases have attracted considerable attention due to their role in microbial resistance to β-lactam antibiotics. IMP-1, the binuclear Zn-dependent β-lactamase produced by Pseudomonas aeruginosa and other microorganisms, is of particular interest in view of its increasing prevalence. An examination of the susceptibility of IMP-1 to inactivation by six different divalent metal ion chelators...
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