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A deoxyribozyme is a catalytic DNA that catalyzes a site-specific RNA cleavage activity and requires various divalent cations. Earlier we have reported that by downsizing the catalytic loop of a deoxyribozyme from 15-mer to 11-mer it resulted in a short and novel Ca 2+ -dependent deoxyribozyme. In this paper, we investigate the complex formation of deoxyribozymes with their RNA substrates...
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