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With the advent of new technologies, human exposure to ionizing radiation has increased. Therefore, appropriate pharmacological interventions and modalities are needed to protect humans against the deleterious effects of ionizing radiation. In this work, we developed a photosensitive, high-throughput chip-based assay for exploring the antioxidant [superoxide dismutase (SOD)]/radioprotective potential...
We have developed a high-throughput chip-based assay that uses a photodiode array (PDA) microchip system to explore the inhibitory effects of drug analogs on Xanthine oxidase (XO). Inhibitory effects of dithranol (anthracene derivative), aminoglutethimide (anti-steroid), cyclosporine A (immunosuppressant) and naringenin (flavonoid) on XO were elucidated using the chip-based assay in the presence or...
Direct measurement of neurotransmitter in a single cell still remains a major challenge. Existing probes have several problems for accurate observation of intracellular component. In recent years, quantum dots (Qdot), with their unique physical, chemical, and optical properties, have been used extensively as probes to visualize several cell membrane receptors and extracellular biomolecules. However,...
Because of increase in bacterial resistance to common antibiotics, antibacterial nanometallopharmaceuticals have been drawing increasing interest. Recent literature reports encouraging results about the bactericidal activity of silver nanoparticles of either a simple or composite nature. We, for the first time, demonstrated that silver nanoparticles (AgNP) undergo a shape dependant interaction with...
SH-03 is a rotenoid-containing deguelin analog. In this study, the anticancer activity and the dynamics of the caspase-mediated apoptotic cascade induced by SH-03 was simultaneously monitored in myeloid leukemia cells using multicolor single cell imaging cytometry as a new drug-screening platform. The constructed single cell imaging cytometer consists of an Ar-ion laser beam, a microscope objective...
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