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The Signal Transduction and Activation of RNA (STAR) protein family regulates different levels of RNA metabolism. STAR proteins have been shown to act as homodimers, and the structure of the QUA1 dimerization region of the GLD-1 protein described in this issue (Beuck et al., 2010) provides a link between homodimerization and the selection of RNA targets.
The AU-rich element (ARE) RNA-binding protein KSRP (K-homology splicing regulator protein) contains four KH domains and promotes the degradation of specific mRNAs that encode proteins with functions in cellular proliferation and inflammatory response. The fourth KH domain (KH4) is essential for mRNA recognition and decay but requires the third KH domain (KH3) for its function. We show that KH3 and...
FMRP, whose lack of expression causes the X-linked fragile X syndrome, is a modular RNA binding protein thought to be involved in posttranslational regulation. We have solved the structure in solution of the N-terminal domain of FMRP (NDF), a functionally important region involved in multiple interactions. The structure consists of a composite fold comprising two repeats of a Tudor motif followed...
The structural basis for recognition between human splicing factors U2AF 65 and SF1/mBBP has recently been elucidated, setting the scene for understanding a key step in pre-mRNA splicing and revealing a new conserved function for RRM proteins.
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