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To compare the effects of intraepididymal quercetin (IE-QE) with those of intraperitoneal quercetin (IP-QE) on testicular torsion/detorsion (TD)-induced ischemia/reperfusion (IR) injury of the testes in an experimental rat model.Twenty-four rats were divided into 4 groups: sham (S), TD, TD treated with IP-QE, and TD treated with IE-QE. The IP-QE group received 20 mg/kg QE intraperitoneally, whereas...
To investigate whether the protective effects of ischemic postconditioning (IPoC) are associated with the modulation of toll-like receptor 4 (TLR4) expression.We subjected Wistar rats to 45 minutes of ischemia followed by reperfusion at 24 hours. Before reperfusion, rats were treated with 6 cycles of 10 seconds of reperfusion followed by 10 seconds of ischemia. Blood samples were collected for the...
To report the relative incidence of the perceived reduction in penile size across prostate cancer treatment modalities and to describe its effect on quality of life and treatment regret.The incidence of patient complaints about reduced penile size was calculated for 948 men in the Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma (COMPARE) registry who experienced biochemical failure...
To investigate whether ischemic postconditioning effects on the development of tubulointerstitial fibrosis follow acute renal ischemia-reperfusion. Rat models of warm renal I/R were established by clamping left pedicles for 45 minutes after right nephrectomy, both with and without treatment with ischemic postconditioning, and then reperfused for up to 12 weeks. Hematoxylin–eosin (H&E) and Masson's...
The present report describes a 6-year-old boy with leiomyoma of the bladder and the imaging characteristics of the lesion, including images from ultrasonography, computed tomography, and the histopathologic examination. Leiomyoma of bladder is extremely rare in children. The present case, to our knowledge, represents the second reported case of bladder leiomyoma in pediatric patients since 1966. Although...
To investigate the effect of Postcond on renal ischemia-reperfusion (I/R) injury in a canine model. I/R injury is the most common cause of renal dysfunction. Ischemic postconditioning (Postcond) is a phenomenon by which intermittent interruptions of blood flow in the early phase of reperfusion can protect organs from I/R injury.Forty adult male mongrel dogs were randomly divided into five groups of...
To evaluate whether the surgical approach influenced the likelihood of a positive surgical margin (PSM) adjusting for known preoperative predictors of PSM, year of radical prostatectomy, body mass index, use of nerve sparing, and patient age at radical prostatectomy.The study cohort comprised 950 consecutively treated men with clinically localized prostate cancer who underwent open radical retropubic...
Lymphangioma in the bladder is extremely rare. An 8-year-old girl presented with a terminal hematuria associated with intermitted fever. Ultrasonography, computed tomogram, and retrograde urethrography showed a mass that was in the wall of the bladder. The tumor was red and found to be bulging into the bladder on the right lateral wall of the bladder by cystoscopy. A partial cystectomy was performed...
We compared the safety and efficacy of transvesical prostatectomy (TVP) and transurethral resection of the prostate (TURP) for prostate greater than 80 mL in a prospective randomized trial.Eighty patients with urodynamic obstruction and prostate volume >80 mL were prospectively randomized and assigned to TVP or TURP. Patients were assessed preoperatively and followed up at 3 and 12 months postoperatively...
To determine whether a novel DNA vaccine encoding truncated human prostate-specific membrane antigen (tPSMA) can be enhanced by a genetically enhanced adjuvant (4-1BB ligand [4-1BBL]).A eukaryotic expression plasmid pDC316-tPSMA-internal ribosome entry site-mouse 4-1BBL (pDC316-tPSMA-IRES-m4-1BBL) was constructed. The efficacy of vaccination using pDC316-tPSMA-IRES-m4-1BBL was compared with pDC316-tPSMA...
To examine whether the time to the prostate-specific antigen (PSA) nadir was associated with prostate cancer-specific mortality (PCSM) in men with PSA failure after radical prostatectomy or radiotherapy who do not achieve an undetectable PSA level (PSA level of 0.2 ng/mL or less) after 8 months of androgen suppression therapy (AST).The cohort included 162 men with localized prostate cancer treated...
To determine the pretreatment factors associated with an undetectable prostate-specific antigen (PSA) nadir after 8 months of androgen suppression therapy (AST).The study cohort comprised 137 men with an increasing PSA level after surgery or radiotherapy performed for localized prostate cancer who had undergone AST. Cox regression multivariate analyses were used to identify the factors associated...
An increasing prostate-specific antigen (PSA) velocity (PSAV) is associated with a shorter time to prostate cancer-specific mortality (PCSM) after definitive local therapy. This study examined the effect on this association when the PSAV was estimated using all PSA values (PSAV-all) instead of the PSA values within 18 months before diagnosis (PSAV-18).We studied 358 men (median age 71.2) with clinically...
Men with high-grade prostate cancer experience a survival benefit when androgen suppression therapy is combined with radiotherapy (RT) compared with RT alone. We evaluated whether an association exists between the pretreatment prostate-specific antigen (PSA) velocity and high-grade prostate cancer at diagnosis, controlling for known predictors of high-grade disease.The study cohort consisted of 358...
To compare the preoperative characteristics, postoperative prostate-specific antigen (PSA) doubling time (DT), and prostate cancer-specific mortality (PCSM) estimates after PSA failure in men diagnosed during a screening study versus a community referral population. A PSA-DT of less than 3 months is a surrogate endpoint for PCSM. From 1988 to 2002, 1492 of 9637 patients with clinically localized...
To determine whether pretreatment risk groups also predict for posttreatment prostate-specific antigen (PSA) doubling times (PSADTs). Pretreatment risk groups predict for posttreatment biochemical failure (BF) after conformal radiotherapy in patients with prostate cancer and posttreatment PSADTs can predict for prostate cancer-related deaths. The study cohort consisted of 416 patients with clinically...
To evaluate whether the maximal tumor diameter (MTD) is significantly associated with the time to postoperative prostate-specific antigen (PSA) failure. Between 1986 and 2002, 781 men with clinical Stage T1c–T2 prostate cancer underwent radical prostatectomy. The MTD was recorded as the maximal dimension of the largest single focus of cancer from all 3-mm step sections. The median follow-up was...
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