Search results for: Masaya Ono

Items from 1 to 20 out of 30 results

article

N‐acetyloxfenicine strongly induces mitohormesis in mice as well as in insects

Takashi Matsumura, Masaya Ono, Satoshi Osada, Fumikazu Matsuhisa, more

Mitohormesis defines the increase in fitness induced by adaptive responses to mild mitochondrial stress. Here, we show that N‐acetyloxfenicine (NAO) exerted higher thermotolerance than an endogenous mitohormesis inducer, N‐acetyltyrosine (NAT). This activity was not observed in armyworm larvae injected with oxfenicine, suggesting the importance of N‐acetylation. NAO‐induced hormetic effect was triggered...

article

Abnormal increases in reactive oxygen species in dying insects infected with nematodes

Urara Tonogawa, Takashi Matsumura, Masaya Ono, Toyoshi Yoshiga

Archives of Insect Biochemistry and Physiology > 106 > 2 > n/a - n/a

Stress enhances the concentration of reactive oxygen species (ROS) in animal plasma. Increased ROS alter various physiological functions, such as development and the immune response, but excessive increases could be harmful. In this study, we tested the hypothesis that abnormally increased plasma ROS levels are associated with animal death. Injection of the nematode Caenorhabditis elegans into insect...

article

Species‐Specific Quantitative Proteomics Profiles of Sarcoma Patient‐Derived Models Closely Reflect Their Primary Tumors

Kumiko Shiozawa, Rieko Oyama, Mami Takahashi, Fusako Kito, more

PROTEOMICS – Clinical Applications > 13 > 6 > n/a - n/a

Purpose The purpose is to examine whether patient‐derived sarcoma models recapitulate the spectrum of sarcoma heterogeneity seen in patients. Experimental design To characterize patient‐derived models for functional studies, proteomic comparisons with originating sarcomas representative of three intrinsic subtypes by MS are performed. Results Human protein profiling is found to be retained with...

article

Intra‐adrenal corticotropin in bilateral macronodular adrenal hyperplasia: Report of two Japanese cases

Hisamitsu Ide, Yan Lu, Masaya Ono, Takuo Tokairin, more

International Journal of Urology > 25 > 3 > 307 - 308

article

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

Yuko Atsumi, Yusuke Minakawa, Masaya Ono, Sachiko Dobashi, more

Cell Reports > 2015 > 13 > 12 > 2728-2740

In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in response to DSBs to efficiently generate γH2AX foci. This mechanism operated even in quiescent cells that barely expressed H2AX. H2AX stabilization resulted from the inhibition of proteasome-mediated degradation. Synthesized H2AX ordinarily...

article

Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas

Eri Arai, Masahiro Gotoh, Ying Tian, Hiromi Sakamoto, more

International Journal of Cancer > 137 > 11 > 2589 - 2606

CpG‐island methylator phenotype (CIMP)‐positive clear cell renal cell carcinomas (RCCs) are characterized by accumulation of DNA hypermethylation of CpG islands, clinicopathological aggressiveness and poor patient outcome. The aim of this study was to clarify the molecular pathways participating in CIMP‐positive renal carcinogenesis. Genome (whole‐exome and copy number), transcriptome and proteome...

article

Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis

Masahiro Kamita, Taiki Mori, Yoshihito Sakai, Sadayuki Ito, more

PROTEOMICS > 15 > 9 > 1622 - 1630

Lumbar spinal stenosis (LSS) is a syndromic degenerative spinal disease and is characterized by spinal canal narrowing with subsequent neural compression causing gait disturbances. Although LSS is a major age‐related musculoskeletal disease that causes large decreases in the daily living activities of the elderly, its molecular pathology has not been investigated using proteomics. Thus, we used several...

article

Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy

Yosuke Makuuchi, Kazufumi Honda, Yoshiaki Osaka, Ken Kato, more

Cancer Science > 104 > 8 > 1045 - 1051

Preoperative chemoradiotherapy has been shown to improve the outcome of patients with esophageal cancer, but because response to this therapy varies, it is desirable to identify in advance individuals who would be unlikely to benefit, in order to avoid unnecessary adverse drug effects. The serum profiles of 84 cytokines and related proteins were determined in 37 patients with esophageal squamous cell...

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ADP-ribosylation of guanosine by SCO5461 protein secreted from Streptomyces coelicolor

Tsuyoshi Nakano, Yuko Matsushima-Hibiya, Masafumi Yamamoto, Azusa Takahashi-Nakaguchi, more

Toxicon > 2013 > 63 > Complete > 55-63

The Streptomyces coelicolor A3(2) genome encodes a possible secretion protein, SCO5461, that shares a 30% homology with the activity domains of two toxic ADP-ribosyltransferases, pierisins and mosquitocidal toxin. We found ADP-ribosylating activity for the SCO5461 protein product through its co-incubation with guanosine and NAD ⁺ , which resulted in the formation of N ² -(ADP-ribos-1-yl)-guanosine...

article

Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray

Yusuke Murakoshi, Kazufumi Honda, Shizuka Sasazuki, Masaya Ono, more

Cancer Science > 102 > 3 > 630 - 638

The development of a new plasma biomarker for early detection would be necessary to improve the overall outcome of colorectal cancer. Here we report the identification and validation of the ninth component of complement (C9) as a novel plasma biomarker for colorectal cancer by cutting‐edge proteomic technologies. Plasma proteins were enzymatically digested into a large array of peptides, and the relative...

article

Regulation of Wnt Signaling by the Nuclear Pore Complex

Miki Shitashige, Reiko Satow, Kazufumi Honda, Masaya Ono, more

Gastroenterology > 2008 > 134 > 7 > 1961-1971.e4

Background & Aims: The function of β-catenin as a transcriptional coactivator of T-cell factor-4 (TCF-4) is crucial for colorectal carcinogenesis. However, β-catenin has no nuclear localization signal, and the mechanisms by which β-catenin is imported into the nucleus and forms a complex with the TCF-4 nuclear protein are poorly understood. Methods: Proteins of 2 colorectal cancer cell lines,...

article

Functional Interaction of DNA Topoisomerase IIα With the β-Catenin and T-Cell Factor-4 Complex

Lin Huang, Miki Shitashige, Reiko Satow, Kazufumi Honda, more

Gastroenterology > 2007 > 133 > 5 > 1569-1578

Background & Aims: The Wnt signaling pathway is activated constitutively in the majority of colorectal cancers as a result of mutation in either the adenomatous polyposis coli or the CTNNB1 gene, and blockage of the pathway has been considered feasible as molecular therapy against colorectal cancer. DNA topoisomerase IIα (Topo IIα) is a component of the β-catenin/T-cell factor-4 (TCF-4) nuclear...

article

Involvement of Splicing Factor-1 in β-Catenin/T-Cell Factor-4-Mediated Gene Transactivation and Pre-mRNA Splicing

Miki Shitashige, Yasuyoshi Naishiro, Masashi Idogawa, Kazufumi Honda, more

Gastroenterology > 2007 > 132 > 3 > 1039-1054

Background & Aims: β-Catenin is the downstream effector of the Wnt signaling pathway and is involved in the process of colorectal carcinogenesis. However, it is still uncertain whether β-catenin exerts its oncogenic function solely by coactivating the target genes of T-cell factor-4 (TCF4). We previously reported that the β-catenin/TCF4 complex contains several classes of RNA-binding proteins...

article

IDENTIFICATION OF 2 SERUM BIOMARKERS OF RENAL CELL CARCINOMA BY SURFACE ENHANCED LASER DESORPTION/IONIZATION MASS SPECTROMETRY

TOMOHIKO HARA, KAZUFUMI HONDA, MASAYA ONO, KATSUSUKE NAITO, more

The Journal of Urology > 2005 > 174 > 4 Part 1 > 1213-1217

Surface enhanced laser desorption/ionization mass spectrometry can generate robust information from a small amount of clinical samples such as serum and plasma. In this study we identified novel diagnostic biomarkers of renal cell carcinoma (RCC) by large-scale serum protein profiling using surface enhanced laser desorption/ionization mass spectrometry. Proteomic spectra were generated by a time...

article

Functional polymorphism in Z-DNA–forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects: Association study and meta-analysis

Masanori Nishino, Hiroshi Ikegami, Tomomi Fujisawa, Yoshihiko Kawaguchi, more

Metabolism > 2005 > 54 > 5 > 628-633

The association of the polymorphism of the Z-DNA–forming repeats in the promoter region of SLC11A1 (solute carrier family 11 member 1), formerly designated NRAMP1 (natural resistance associated macrophage protein 1), with type 1 diabetes was studied in a total of 244 Japanese subjects. Three alleles were detected in Japanese subjects. In diabetic patients, allele 2 was less frequent and allele 3 was...

article

Improvement of liver function parameters in patients with type 2 diabetes treated with thiazolidinediones

Masaya Ono, Hiroshi Ikegami, Tomomi Fujisawa, Koji Nojima, more

Metabolism > 2005 > 54 > 4 > 529-532

To increase our understanding of the effect of thiazolidinediones, a new class of antidiabetic drugs, on liver function as well as glycemic control, we investigated liver function before, during, and after treatment with troglitazone and pioglitazone.A total of 32 patients with type 2 diabetes were studied. Glycemic control and liver function were measured before, during, and after 4 to 12 weeks of...

article

Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin-converting enzyme inhibitor in diabetic nephropathy

Tomomi Fujisawa, Hiroshi Ikegami, Masaya Ono, Masanori Nishino, more

American Journal of Hypertension > 2005 > 18 > 1 > 13-17

To investigate the renoprotective effect of combination therapy with an angiotensin I converting enzyme inhibitor and an angiotensin type I receptor blocker (ARB) on diabetic kidney disease, half doses of each monotherapy were given to type 2 diabetic patients with albuminuria. Urinary albumin index (UAI) and blood pressure (BP) were measured in a total of 27 outpatients with type 2 diabetes mellitus...

article

Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer

Kazufumi Honda, Tesshi Yamada, Yasuharu Hayashida, Masashi Idogawa, more

Gastroenterology > 2005 > 128 > 1 > 51-62

Background & Aims: Enhanced motility of cancer cells by remodeling of the actin cytoskeleton seems crucial in the process of cancer invasion and metastasis. We previously identified an actin-binding protein, actinin-4, as a new biomarker of cancer invasion and an indicator of prognosis for patients with breast cancer. However, its involvement in the mechanisms of cancer invasion and metastasis...

article

Association of Pro12Ala polymorphism of PPARγ gene with insulin resistance and related diseases

Mayumi Horiki, Hiroshi Ikegami, Tomomi Fujisawa, Yumiko Kawabata, more

Diabetes Research and Clinical Practice > 2004 > 66 > Supplement > S63-S67

To clarify the contribution of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ (PPARγ) gene to susceptibility to insulin resistance and related diseases, 505 unrelated Japanese subjects were investigated, including 175 normotensive non-diabetic (NN) subjects, 125 normotensive diabetic (ND) subjects, 102 hypertensive non-diabetic (HN) subjects, and 103 hypertensive diabetic...

article

Common genetic basis between type 1 and type 2 diabetes mellitus indicated by interview-based assessment of family history

Tomomi Fujisawa, Hiroshi Ikegami, Yoshihiko Kawaguchi, Koji Nojima, more

Diabetes Research and Clinical Practice > 2004 > 66 > Supplement > S91-S95

To investigate the intrafamilial clustering of type 1 and type 2 diabetes, an interview-based assessment of family history of diabetes was conducted. Outpatients with either type 1 (n = 23) or type 2 diabetes (n = 124), and non-diabetic subjects (n = 118) received an interview regarding the diabetic status of each of their family members. In patients with type 1 diabetes, 22% (5 out of 23) had a parental...

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INFONA - science communication portal

Search results for: Masaya Ono

N‐acetyloxfenicine strongly induces mitohormesis in mice as well as in insects

Abnormal increases in reactive oxygen species in dying insects infected with nematodes

Species‐Specific Quantitative Proteomics Profiles of Sarcoma Patient‐Derived Models Closely Reflect Their Primary Tumors

Intra‐adrenal corticotropin in bilateral macronodular adrenal hyperplasia: Report of two Japanese cases

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas

Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis

Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy

ADP-ribosylation of guanosine by SCO5461 protein secreted from Streptomyces coelicolor

Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray

Regulation of Wnt Signaling by the Nuclear Pore Complex

Functional Interaction of DNA Topoisomerase IIα With the β-Catenin and T-Cell Factor-4 Complex

Involvement of Splicing Factor-1 in β-Catenin/T-Cell Factor-4-Mediated Gene Transactivation and Pre-mRNA Splicing

IDENTIFICATION OF 2 SERUM BIOMARKERS OF RENAL CELL CARCINOMA BY SURFACE ENHANCED LASER DESORPTION/IONIZATION MASS SPECTROMETRY

Functional polymorphism in Z-DNA–forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects: Association study and meta-analysis

Improvement of liver function parameters in patients with type 2 diabetes treated with thiazolidinediones

Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin-converting enzyme inhibitor in diabetic nephropathy

Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer

Association of Pro12Ala polymorphism of PPARγ gene with insulin resistance and related diseases

Common genetic basis between type 1 and type 2 diabetes mellitus indicated by interview-based assessment of family history

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