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Synthetic Organelles
In article number 2301856, Hang Zhao, Sébastien Lecommandoux, and co‐workers report mimicking of intracellular stress membraneless organelles, elastin‐like polypeptide‐derived components that are enclosed in partially dewetted liposomes, which enables rapid response to hyperosmotic stress through liquid–liquid phase separation. This assembles biofunctional synthetic organelles,...
In response to variations in osmotic stress, in particular to hypertonicity associated with biological dysregulations, cells have developed complex mechanisms to release their excess water, thus avoiding their bursting and death. When water is expelled, cells shrink and concentrate their internal bio(macro)molecular content, inducing the formation of membraneless organelles following a liquid–liquid...