The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Phänotypen für die Suche nach neuartigen Therapeutika zu nutzen, wird durch die langwierige Zieldekonvolution erschwert. In der Zuschrift auf S. 5202 ff. stellen S. B. Park et al. eine konvergente Strategie des Phänotyp‐Screenings mit frühzeitiger Identifizierung des Ziels vor, die die Lücke zwischen Phänotyp‐basierter Entdeckung von Treffern und rationaler Wirkstoffentwicklung überbrückt und so zu...
Small‐molecule glucose uptake enhancers targeted to myotubes and adipocytes were developed through a phenotypic screening linked with target identification and rational optimization. The target protein of glucose‐uptake enhancers was identified as a nuclear receptor PPARγ (peroxisome proliferator‐activated receptor gamma). Subsequent optimization of initial hits generated lead compounds with high...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.