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A new approach to construct a single dual-acting agent is described. Compounds 6a–c are potent free radical scavengers as demonstrated by the EC 50 values in PC12 cell survival assay in term of NO, H 2 O 2 , and OH scavenging activity. The Ach-induced vaso-relaxation assay further confirms the potent NO scavenging activity of compounds 6a–c. In addition, 6a–c are efficacious...
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