Search results for: Hyejung Mok

Items from 1 to 20 out of 68 results

article

Effects of Histidine Oligomers in Lipid Nanoparticles on siRNA Delivery

Hyeondo Lee, Gayeon You, Sangho Yeo, Hyukjin Lee, more

Macromolecular Bioscience > 24 > 8 > n/a - n/a

In this study, histidine oligomer (oHis; 10mer)‐incorporating LNPs (H10LNPs) are developed as a novel carrier for efficient siRNA delivery. Notably, the unmodified oHis (10mer) is greatly incorporated within LNPs through ionic interaction with siRNAs, which serves as an endosome escape enhancer. H10LNPs with a size of ≈65 nm demonstrate a significantly enhanced extent of endosomal escape, as evidenced...

article

Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine‐Incorporated Lipid Nanoparticles

In Gyu Kim, Won Ho Jung, Gayeon You, Hyukjin Lee, more

Macromolecular Bioscience > 23 > 4 > n/a - n/a

In this study, a novel polyhistidine‐incorporated lipid nanoparticle (pHis/LNP) is developed for the delivery of therapeutic globotriaosylceramide (Gb3) synthase siRNAs using a microfluidic device with pHis as a biocompatible method of endosome escape. To inhibit the expression of Gb3 synthase, six siRNAs against Gb3 synthase are designed and an optimal siRNA sequence is selected. Selected Gb3 synthase...

article

Cancer‐Cell‐Derived Hybrid Vesicles from MCF‐7 and HeLa Cells for Dual‐Homotypic Targeting of Anticancer Drugs

Jihyeon Song, Heesun Jung, Gayeon You, Hyejung Mok

Macromolecular Bioscience > 21 > 7 > n/a - n/a

Here, as a proof of concept, hybrid vesicles (VEs) are developed from two types of cancer cells, MCF‐7 and HeLa, for the dual targeting of the anticancer drug doxorubicin (Dox) to cancer cells via homotypic interactions. Hybrid VEs with a size of 181.8 ± 28.2 nm and surface charge of −27.8 ± 1.9 mV are successfully prepared by the fusion of MCF‐7 and HeLa VEs, as demonstrated by the fluorescence resonance...

article

Activated Platelet‐Derived Vesicles for Efficient Hemostatic Activity

Joo Hang Lee, Heesun Jung, Jihyeon Song, Eun Seo Choi, more

Macromolecular Bioscience > 20 > 3 > n/a - n/a

In this study, activated platelet‐derived vesicles (Act‐VEs) are developed as a novel hemostatic biomaterial. Spherical Act‐VEs (114.40 ± 11.69 nm in size) with surface charges of −24.73 ± 1.32 mV are successfully prepared from thrombin‐activated murine platelets with high surface expression of active glycoprotein IIb/IIIa (GP IIb/IIIa, also known as αIIbβ3) and P‐selectin. Although nanosized vesicles...

article

Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation

Eun Seo Choi, Jihyeon Song, Yoon Young Kang, Hyejung Mok

Macromolecular Bioscience > 19 > 7 > n/a - n/a

The surface of bovine serum‐derived exosomes (EXOs) are modified with α‐d‐mannose for facile interaction with mannose receptors on dendritic cells (DCs) and for efficient delivery of immune stimulators to the DCs. The surface of the EXOs is modified with polyethylene glycol (PEG) without particle aggregation (≈50 nm) via the incorporation of 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine (DSPE) into...

article

Citraconylated exosomes for improved internalization into macrophages

Youngjun Kim, Hyejung Mok

Applied Biological Chemistry > 2019 > 62 > 1 > 1-7

Considering the close relation between macrophages and inflammatory diseases, the design of carriers for the delivery of drugs, genes, and small molecules into macrophages is crucial. In this study, the surface charge of exosome (EXO) was easily modified to highly negative charge by citraconylation. Prepared citraconylated EXO (cit-EXO) exhibited a significantly reduced surface charge down to − 50...

article

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Ok Park, Eun Seo Choi, Gyeonghui Yu, Jun Yeong Kim, more

Macromolecular Bioscience > 18 > 12 > n/a - n/a

Exosomes (EXO) are considered to be versatile carriers for biomolecules; however, the delivery of therapeutic peptides using EXOs poses several challenges. In this study, the efficiency of serum‐derived EXOs in delivering tyrosinase‐related protein‐2 (TRP2) peptides to lymph nodes is determined. TRP2 peptides are successfully incorporated into EXOs, which show a uniform and narrow size distribution...

article

I-motif-coated exosomes as a pH-sensitive carrier for anticancer drugs

Jun Yeong Kim, Jihyeon Song, Heejung Jung, Hyejung Mok

Applied Biological Chemistry > 2018 > 61 > 6 > 599-606

Nature-derived exosomes have been noted as emerging carriers for anticancer drugs. In this study, as a proof-of-concept, the anticancer drug doxorubicin (Dox) was loaded onto i-motif-modified exosomes (Exo-i-motif) to deliver Dox to cancer cells efficiently. The double-stranded biotin-i-motif/flare (ds-i-motif-bio)s efficiently released Dox in an acidic pH-responsive manner within 1 h. Based on gel...

article

Effects of curcumin-/boron-based compound complexation on antioxidant and antiproliferation activity

Jun Yeong Kim, Yoon Young Kang, Eun Ji Kim, Joong-Hoon Ahn, more

Applied Biological Chemistry > 2018 > 61 > 4 > 403-408

Simple and reproducible formulation strategies are needed to improve the bio-availability of curcumin. In this study, curcumin was successfully complexed with two boron-based compounds: 2-aminoethyl diphenyl borate (DPBA) and bortezomib (BTZ; Velcade^®). In reverse-phase high-performance liquid chromatography, DPBA/curcumin complexes (DPBA/cur) showed delayed elution times compared to those of free...

article

Evaluation of the Enhanced Antioxidant Activity of Curcumin within Exosomes by Fluorescence Monitoring

Eun Seo Choi, Yoon Young Kang, Hyejung Mok

Biotechnology and Bioprocess Engineering > 2018 > 23 > 2 > 150-157

In this study, we compared the antioxidant activities of curcumin (Cur) and a Cur formulation using a fluorescence analysis assay. The Cur formulation was prepared by a simple incorporation of Cur into exosomes (EXO) to produce Cur/EXOs. Free Cur had a low fluorescence intensity in aqueous solution because of its poor stability as a result of its autoxidation, whereas a significantly higher fluorescence...

article

Analysis of the biodistribution of natural products in mice by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Hye-Jeong Hwang, Inseong Choi, Yoon Young Kang, Hyejung Mok, more

Applied Biological Chemistry > 2018 > 61 > 2 > 251-255

Natural products originating from plants have various beneficial pharmacological effects, such as anticancer, antimicrobial, and anti-inflammatory activities, while being nontoxic. Therefore, tremendous efforts have been invested in understanding their bioactivities in the body to facilitate therapeutic target validation. However, such research is still challenging for certain natural products, such...

article

Curcumin-Incorporated Polymeric Scaffolds and Their Potential for the Detection of Radical Molecules

Ok Park, Chae Hwa Kim, Yoon Jin Kim, Hee Sun Jung, more

Macromolecular Research > 2018 > 26 > 2 > 145-150

Reactive oxygen species (ROS)-responsive imaging systems could serve as probes for fluorescence detection at wound sites. In this study, curcumin-incorporated polymeric scaffolds were prepared, and their potential for the rapid detection of radical molecules as a wound stage marker was examined. Two types of nonwoven scaffolds, based on poly(lactic-co-glycolic) acid (PLGA)/poly(lactic acid) (PLA)...

article

Biological synthesis and anti-inflammatory activity of arylalkylamine

Min Kyung Song, Su Jin Lee, Yoon Young Kang, Youngshim Lee, more

Applied Biological Chemistry > 2017 > 60 > 6 > 597-602

Hydroxycinnamic acid amides (HCAAs) are natural compounds with antifungal, anticancer, and anti-inflammatory activities. Extraction from plants and chemical synthesis have been the major approaches to obtain these compounds. We used a biological method to synthesize HCAA derivatives (arylalkylamines). Two genes, SHT encoding serotonin N-hydroxycinnamoyl transferase and 4CL encoding 4-coumaroyl-CoA...

article

Cleavable conjugation of CpG oligodeoxynucleotides onto microparticles for facile release and cytokine induction in macrophages

Hyo-Eun Jang, Heejung Jung, Hyejung Mok

Applied Biological Chemistry > 2017 > 60 > 3 > 321-326

The development of biomaterials for efficient intracellular delivery of the nucleic acid-based immune-stimulating molecule, CpG oligodeoxynucleotides (CpG), is crucial for their biological activity. In this study, we successfully fabricated polydopamine-coated porous poly(lactic-co-glycolic acid) microparticles (PPM) for the delivery of CpGs. After conjugation of CpGs to PPMs via cleavable disulfide...

article

Multivalent Aptamer–RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug‐Resistant Cells

Hyosook Jeong, Soo Hyeon Lee, Yeonju Hwang, Hyundong Yoo, more

Macromolecular Bioscience > 17 > 4 > n/a - n/a

Multivalent aptamer–siRNA conjugates containing multiple mucin‐1 aptamers and BCL2‐specific siRNA are synthesized, and doxorubicin, an anthracycline anticancer drug, is loaded into these conjugates through intercalation with nucleic acids. These doxorubicin‐incorporated multivalent aptamer–siRNA conjugates are transfected to mucin‐1 overexpressing MCF‐7 breast cancer cells and their multidrug‐resistant...

article

Complexation of curcumin with 2-aminoethyl diphenyl borate and implications for spatiotemporal fluorescence monitoring

Yoon Young Kang, Heesun Jung, Gyeonghui Yu, Youhoon Chong, more

International Journal of Pharmaceutics > 2016 > 515 > 1-2 > 669-676

In this study, we successfully determined spatiotemporal distribution of curcumin in mice via simple and fast fluorescence detection of native curcumin and stabilized curcumin. We used 2-aminoethyl diphenyl borate (DPBA) as a stabilizer of curcumin, which binds to curcumin and enhances its aqueous stability. After intravenous injection, curcumin and DPBA–curcumin complexes showed similar fluorescence...

article

Recent studies on micro-/nano-sized biomaterials for cancer immunotherapy

Ok Park, Gyeonghui Yu, Heejung Jung, Hyejung Mok

Journal of Pharmaceutical Investigation > 2017 > 47 > 1 > 11-18

To overcome the suppressive tumor microenvironment and boost the antitumor effect of the immune system, recent studies have focused on a diverse range of immune checkpoint molecules. Several immune checkpoint molecules are currently approved for clinical use, including immunotherapy using antibodies against cytotoxic T-lymphocyte antigen-4 and programmed cell death protein-1. Biomaterials such as...

article

Polydopamine‐Coated Porous Microspheres Conjugated with Immune Stimulators for Enhanced Cytokine Induction in Macrophages

Hyo‐Eun Jang, Hyejung Mok

Macromolecular Bioscience > 16 > 11 > 1562 - 1569

Polydopamine‐coated porous microsphere (PPM) is investigated as a simple and versatile immobilization strategy for immune‐stimulating biomolecules to enhance delivery efficiency and immune‐stimulating effects such as cytokine induction in macrophages. The PPMs, with diameters of about 2 μm, exhibit simultaneous and efficient incorporation of biomolecules (nucleotides and proteins), which is comparable...

article

CpG oligonucleotide and α-d-mannose conjugate for efficient delivery into macrophages

Heesun Jung, Gyeonghui Yu, Hyejung Mok

Applied Biological Chemistry > 2016 > 59 > 5 > 759-763

For improved intracellular uptake of CpG ODN into macrophages, we developed CpG ODN and mannose conjugate (CpG–Man conjugate) via simple conjugation of α-d-mannose to CpG ODN. CpG–Man conjugate showed greatly enhanced intracellular uptake by 2.1-fold into macrophages, compared to CpG ODN in a TLR-9 receptor-specific manner. In addition, internalized CpG–Man conjugate successfully triggered TNF-α release...

article

Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics

Soo Hyeon Lee, Yoon Young Kang, Hyo-Eun Jang, Hyejung Mok

Advanced Drug Delivery Reviews > 2016 > 104 > C > 78-92

Recent promising clinical results of RNA therapeutics have drawn big attention of academia and industries to RNA therapeutics and their carrier systems. To improve their feasibility in clinics, systemic evaluations of currently available carrier systems under clinical trials and preclinical studies are needed. In this review, we focus on recent noticeable preclinical studies and clinical results regarding...

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CYTOKINE (4)
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INFONA - science communication portal

Search results for: Hyejung Mok

Effects of Histidine Oligomers in Lipid Nanoparticles on siRNA Delivery

Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine‐Incorporated Lipid Nanoparticles

Cancer‐Cell‐Derived Hybrid Vesicles from MCF‐7 and HeLa Cells for Dual‐Homotypic Targeting of Anticancer Drugs

Activated Platelet‐Derived Vesicles for Efficient Hemostatic Activity

Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation

Citraconylated exosomes for improved internalization into macrophages

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

I-motif-coated exosomes as a pH-sensitive carrier for anticancer drugs

Effects of curcumin-/boron-based compound complexation on antioxidant and antiproliferation activity

Evaluation of the Enhanced Antioxidant Activity of Curcumin within Exosomes by Fluorescence Monitoring

Analysis of the biodistribution of natural products in mice by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Curcumin-Incorporated Polymeric Scaffolds and Their Potential for the Detection of Radical Molecules

Biological synthesis and anti-inflammatory activity of arylalkylamine

Cleavable conjugation of CpG oligodeoxynucleotides onto microparticles for facile release and cytokine induction in macrophages

Multivalent Aptamer–RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug‐Resistant Cells

Complexation of curcumin with 2-aminoethyl diphenyl borate and implications for spatiotemporal fluorescence monitoring

Recent studies on micro-/nano-sized biomaterials for cancer immunotherapy

Polydopamine‐Coated Porous Microspheres Conjugated with Immune Stimulators for Enhanced Cytokine Induction in Macrophages

CpG oligonucleotide and α-d-mannose conjugate for efficient delivery into macrophages

Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics

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