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Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Herein, we report the synthesis and in vitro evaluation of anti-NS5B polymerase activity of a molecular hybrid of our previously reported lead compounds 1 (IC 50 =7.7μM) and 2 (IC 50 =10.6μM) as represented by hybrid compound 27 (IC 50 =6.7μM). We have explored the optimal substituents...
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