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Poly (lactic acid) (PLA) is typical biocompatible polymer, and is widely used in drug delivery application. For the production of polymeric microspheres loaded with the pharmaceutical, the supercritical fluid technology using carbon difoxide (CO2) is favor because of non-toxic nature. In this work, the phase behaviors of PLA in various supercritical solvents such as dimethyl ether (DME), CO2, chlorodifluoromethane...
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