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Several quinazoline derivatives were made as mitochondrial complex 1 inhibitors. Compound 4 showed an IC 50 of 11.3nM and was the most potent compound of this series. The 18 F analog of 4, [ 18 F] 4, was injected in the rat and showed high and rapid heart uptake, fast liver clearance, and low blood uptake. Images obtained using a μPET showed clear delineation of the myocardium...
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