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Indomethacin N-acyllactam esters 1-6 were synthesized and assayed to determine their water and isopropylmyristate (IPM) stability, susceptibility to undergoing in vitro enzymatic hydrolysis and flux through excised human skin. Esters 1-6 showed poor stability in phosphate buffer pH 7.4 while they were stable in IPM over a period of 48 h. All the prodrugs, apart from derivative 6, were readily hydrolyzed...
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