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Pyroptosis is a newly discovered inflammatory form of programmed cell death, which promotes systemic immune response in cancer immunotherapy. GSDMD is one of the key molecules executing pyroptosis, while therapeutical delivery of GSDMD to tumor cells is of great challenge. In this study, an extracellular vesicles‐based GSDMD‐N mRNA delivery system (namely EVTx) is developed for enhanced cancer immunotherapy,...
Engineered Extracellular Vesicles
In article number 2204031, Jing Zhao, Guodong Yang, Angang Yang, and co‐workers develop an extracellular vesicle‐based GSDMD‐N mRNA delivery system (EVTx), in which GSDMD‐N mRNA is encapsulated inside the vesicle, HER2 antibody is displayed on the surface, and sonosensitizer Ce6 is incorporated into the membrane. When endocytosed by HER2+ cancer cells, EVTx efficiently...
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