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• Sphingomyelin (SM) is a structural component of plasma membrane and may participate in signal transduction. The role of SM metabolism in hearing remains controversial.
• Here we examined hearing in mice deficient of SM synthase‐1 (SMS1) or SMS2, and show that only deficiency of SMS1 causes hearing loss.
• The hearing loss in SMS1 knockout mice is attributable at least in part to a reduction of endocochlear...
Non‐technical summary Interstitial cells of Cajal (ICC) are tightly associated with excitatory and inhibitory motor neurons in the gastrointestinal tract, and these cells are also connected electrically to smooth muscle cells. We have suggested that ICC participate in responses to neurotransmitters released from neurons that drive motility and help move nutrients and wastes through the gut. We studied...
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