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Histone modifications play an important role in eukaryotic gene regulation. However, the dynamic alteration of histone modification during development is poorly understood. In addition, the relationship between histone modification and globin gene switching remains unclear. Here, we assessed the dynamic pattern of histone modification (H3 acetylation, H4 acetylation, H3 K4 methylation, and H3 K79...
Chromatin structure plays a critical role in eukaryotic gene transcriptional regulation. The β-globin locus provides an ideal system within which to study the interplay between chromatin structure and transcriptional regulation. The process of β-globin locus activation is remarkably intricate and involves at least two distinct events: chromatin opening and gene activation. Great progress has been...
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