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New antioxidants as antibiotic substitutes are urgently required in aquaculture as their liver protection and anti‐inflammatory effects. To explore the potential value of American cockroach (Periplaneta americana) powder water extract (ACPWE) as an antioxidant substitute for genetically improved farmed tilapia (GIFT, Oreochromis niloticus), different concentrations of ACPWE were added to the GIFT...