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A novel measure for analysis of multivariate signals in the time-frequency-space domain, the normalized Gabor entropy (NGE), is introduced and applied to multichannel intracranial EEG (iEEG) recordings hours prior to seizures onset in two patients with focal epilepsy. NGE profiles showed a statistically significant progressive decrease of NGE values at epileptogenic focus-related channels as time...
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but its genetic etiology is largely unknown and likely complex involving multiple genes. The Kcna1 gene encodes Kv1.1 potassium channels that act to dampen neuronal excitability whereas the Scn2a gene encodes Nav1.2 sodium channels important for action potential conduction. We tested the hypothesis that...
The measure of Generalized Partial Directed Coherence (GPDC) and surrogate data analysis of intracranial electroencephalographic (iEEG) signals can be used to determine the functional connections between brain sites. Characteristics of the nodes of the thus derived network during seizures from 9 patients with temporal lobe epilepsy were studied using centrality measures (Degree, Eigenvector, Katz,...
A seizure prediction system has the potential to significantly help patients with epilepsy. For a seizure forecasting system to work effectively, computational algorithms must reliably identify periods with high probability of seizure occurrence. We herein report results of a classification approach based on machine learning of EEG features in the frequency domain and aimed at differentiating between...
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