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Cell mechanics is an emerging field of research for translational medicine. Here, the cell is modeled as poroelastic cytoplasm wrapped by tensile membrane (poroelastic@membrane model) and is characterized by the atomic force microscopy (AFM). The parameters of cytoskeleton network modulus EC, cytoplasmic apparent viscosity ηC, and cytoplasmic diffusion coefficient DC are used to describe the mechanical...
Nanomedicine
In article number 2301307, Yan Liu, Xiang Li, and co‐workers report a novel engineered magnetic nanodrug based on Fe3O4 vortex nanorods coated with a macrophage membrane loaded with doxorubicin and EZH2 siRNA. This novel nanodrug has synergistic activity chemotherapy and gene therapy, which shows promising clinical application potential in triple‐negative breast cancer (TNBC) therapy...
Triple‐negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe3O4 vortex nanorods coated with a macrophage membrane loaded with doxorubicin (DOX) and Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) siRNA. This novel...
Tumor‐dependent glucose and glutamine metabolisms are essential for maintaining survival, while the accordingly metabolic suppressive therapy is limited by the compensatory metabolism and inefficient delivery efficiency. Herein, a functional metal–organic framework (MOF)‐based nanosystem composed of the weakly acidic tumor microenvironment‐activated detachable shell and reactive oxygen species (ROS)‐responsive...
The widespread preexisting immunity against virus‐like particles (VLPs) seriously limits the applications of VLPs as vaccine vectors. Enabling technology for exogenous antigen display should not only ensure the assembly ability of VLPs and site‐specific modification, but also consider the effect of preexisting immunity on the behavior of VLPs in vivo. Here, combining genetic code expansion technique...
Intracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the world, and surgery is still the most direct and effective way to remove ICH. However, the potential risks brought by surgery, such as normal brain tissue damage, post‐operative infection, and difficulty in removing deep hematoma, are still the main problems in the surgical treatment of ICH. Activation...
The lithium–sulfur (Li–S) battery is considered as one of the most promising options because the redox couple has almost the highest theoretical specific energy (2600 Wh kg−1) among all solid anode‐cathode candidates for rechargeable batteries. The “solid–liquid–solid” mechanism has become a dominating phase transformation process since it was first reported, although this cathode mode suffers from...
Photodynamic therapy (PDT) of cancers is seriously restricted by tumor hypoxia. In addition to the intrinsic hypoxic microenvironment, continuous photoirradiation further aggravates intratumoral hypoxia, thereby reducing the PDT effect significantly. Oxygen‐independent PDT is recognized as an efficient approach to overcome this issue. Herein, singlet oxygen (1O2)‐stored covalent organic framework...
Defect states play an important role in the photovoltaic performance of metal halide perovskites. Particularly, the passivation of surface defects has made great contributions to high‐performance perovskite photovoltaics. This highlights the importance of understanding the surface defects from a fundamental level by developing more accurate and operando characterization techniques. Herein, a strategy...
Inspired by the 2D bilayer lipid membranes in nature, a unique supramolecular “push–pull” synergetic strategy toward self‐assembled 2D organic crystals (2DOCs) is proposed in this work, which can effectively suppress the interlayer 3D stacking while maintaining the assembly of the intralayer for 2D growth. For this purpose, a model molecule PF‐Py consisting of a planar supramolecular “attractor” and...
Liquid metal‐based metamaterials show great potential in soft robots, flexible electronics and biomedical applications. In article number 2004190, Yang Lu and co‐workers report gallium (Ga)‐filled microlattice metamaterials fabricated by projection micro‐stereolithography (PμSL) 3D printing, which exhibit exceptional toughness and recoverability due to the tunable properties of Ga at relatively low...
Biological materials exhibit excellent fracture toughness due to their ability to dissipate energy during crack propagating through the combination of various constituents with different stiffnesses. Replicating this mechanism in engineering materials is important in mechanical systems and emerging applications such as flexible electronics and soft robotics. Here a novel liquid metal (LM)‐filled polymer...
The incidence of triple‐negative breast cancer (TNBC) is difficult to predict, and TNBC has a high mortality rate among women worldwide. In this study, a theranostics approach is developed for TNBC with ratiometric photoacoustic monitored thiol‐initiated hydrogen sulfide (H2S) therapy. The ratiometric photoacoustic (PA) probe (CY) with a thiol‐initiated H2S donor (PSD) to form a nanosystem (CY‐PSD...
The self‐assembly of bowlic supramolecules on graphene surface is studied with single molecular sensitivity. This is achieved by incorporating a heavy metal tag in the form of a single W atom into the tip of the molecular structure, which enables the direct imaging of molecular distribution using annular dark‐field scanning transmission electron microscopy (ADF‐STEM) along with graphene as an electron...
Metal hydroxide nanomaterials are widely applied in the energy and environment fields. The electrochemical performance of such materials is strongly dependent on their crystal phases. However, as there are always multiple factors relating to the phase‐dependent electrochemistry, it is still difficult to identify the determining one. The well‐defined crystal phases of α‐ and β‐FeOOH nanorods are characterized...
The measurement of ultralow concentrations of heavy metal ions (HMIs) in blood is challenging. A new strategy for the determination of mercury ions (Hg2+) based on an oriented ZnO nanobelt (ZnO‐NB) film solution‐gated field‐effect transistor (FET) chip is adopted. The FET chips are fabricated with ZnO‐NB film channels with different orientations utilizing the Langmuir–Blodgett (L–B) assembly technique...
Cancer stem‐like cells (CSCs) have been shown to initiate tumorigenesis and cancer metastasis in many cancer types. Although identification of CSCs through specific marker expression helps define the CSC compartment, it does not directly provide information on how or why this cancer cell subpopulation is more metastatic or tumorigenic. In this study, the functional and biophysical characteristics...
Localized cancer treatment is one of the most effective strategies in clinical destruction of solid tumors at early stages as it can minimize the side effects of cancer therapeutics. Electrospun nanofibers have been demonstrated as a promising implantable platform in localized cancer treatment, enabling the on‐site delivery of therapeutic components and minimizing side effects to normal tissues. This...
As one of the reduction species, glutathione (GSH) plays a tremendous role in regulating the homeostasis of redox state in living body. Accurate imaging of GSH in vivo is highly desired to provide a real‐time visualization of physiological and pathological conditions while it is still a big challenge. Recently developed photoacoustic imaging (PAI) with high resolution and deep penetration characteristics...
In article number 1703400, Quli Fan and co‐workers develop a cyanine derivative‐based nanoprobe with specific GSH sensing capability by taking advantage of the single composition architecture design, which permits noninvasive real‐time ratiometric photoacoustic imaging of GSH in the tumors of living mice.
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