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Mebendazole (MBZ) and related anticancer benzimidazoles act binding the β-subunit of Tubulin (TU) before dimerization with α-TU with subsequent blocking microtubule formation. Laser flash photolysis (LFP) is a new tool to investigate drug–albumin interactions and to determine binding parameters such as affinity constant or population of binding sites. The aim of this study was to evaluate the interactions...
Fenbendazole (1) is a common veterinary anthelmintic, toxic to water living microorganisms. Fluorescence quantum yields of 1 were found to be 0.11 in acetonitrile, 0.068 in methanol, 0.034 in cyclohexane, and 0.013 in water. The singlet excited state energy was ca. 96kcalmol −1 in all solvents. The phosphorescence spectrum of 1 in ethanol at 77K displayed a maximum at 450nm, leading to a triplet...
Fluorescence spectroscopy, laser flash photolysis (LPF), and density functional theory calculations have been performed to characterize the photobehavior of thiabendazole (1). Direct LFP of 1 results in the generation of a transient absorbing at λ max =570nm identified as the triplet excited state ( 3 1 ∗ ). The intersystem crossing quantum yield is 0.91, and the triplet energy...
The development of two sensitive and selective immunosensors for sulfathiazole, using immunoreagents – haptens, polyclonal antibodies, enzyme conjugates – previously obtained and characterized, is presented. One of them is based on the competitive immunocomplex capture format making use of an immobilized protein A/G sorbent, while the other employs a restricted access support in a novel homogeneous–heterogeneous...
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