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The colorimetric enantiodiscrimination between mandelic acid and l-proline-Cu (II) is exploited to develop enantioselective indicator displacement assays. The sensitivity of the assay could be tuned by using a colorimetric indicator. The chromophoric ligand, pyrocatechol violet, effectively competes with the mandelic acid guest for open coordination sites on l-proline-Cu (II). The ΔA could be increased...
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