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Summary
Background
The development of neutralizing antibodies (inhibitors) against factor VIII (FVIII) is the most severe complication in the early phases of treatment of severe hemophilia A. Recently, a randomized trial, the Survey of Inhibitors in Plasma‐Product Exposed Toddlers (SIPPET) demonstrated a 2‐fold higher risk of inhibitor development in children treated with recombinant FVIII...
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