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In recent years, liquid chromatography with tandem mass spectrometry (LC–MS/MS) has become a fundamental technology in clinical practice. In Japan, the LC–MS/MS system is used in many large hospitals. It has become popular among pharmacists and laboratory technicians. LC–MS/MS has some advantages in terms of accuracy, speed, and comprehensiveness compared to conventional automated chemical testing...
Recent studies have shown that therapeutic drug monitoring of tyrosine kinase inhibitors (TKIs) could improve treatment efficacy and safety. A simple analytical method using high‐performance LC/electrospray ionization–tandem mass spectrometry has been developed and validated for simultaneous quantification of BCR‐ABL and Bruton’s TKIs used for chronic leukemia (imatinib, dasatinib, bosutinib, nilotinib,...