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Purpose. It has been shown that transport(s) are involved in the uptake of estradiol 17β glucuronide (E217βG) by the choroid plexus (CP). The purpose of this study is to compare the substrate specificity of the transporter in the CP with those of rat organic anion transporting polypeptide 1 (rOatp1) and rOatp3. Methods. The expression of rOatp1 and rOatp3 in rat CP was confirmed by RT-PCR and...
Purpose. The local absorption kinetics of levofloxacin from the intestinal tract was quantitatively evaluated by simultaneously measuring the portal and venous plasma concentrations in a conscious rat. Methods. The venous and upper portal blood vessels were cannulated through the jugular and pyloric veins, respectively. After oral or intravenous administration of levofloxacin, portal and venous...
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