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The opportunistic fungal pathogen Candida albicans occupies various niches of the human body such as the skin and the mucosal surfaces of the gastrointestinal and urogenital tracts. It can also enter the blood stream and cause deadly, systemic infections, especially in immunocompromised patients, but also in immunocompetent individuals through inserted medical devices. To survive in these diverse...
The pathogenic fungus Candida albicans secretes a considerable number of hydrolases and other proteins. In‐depth studies of the C. albicans secretome could thus provide new candidates for diagnostic markers and vaccine development. We compared various growth conditions differing in pH, temperature and the presence of the hyphal inducer N‐acetylglucosamine. The polypeptide content of the growth media...
The covalently linked wall proteins of Saccharomyces cerevisiae and Candida albicans and to a lesser extent of Candida glabrata have been extensively studied. Here we describe some of their main structural features and discuss their conservation in other ascomycetous fungi. We also discuss the hybrid nature of many wall proteins and the frequent occurrence of families of wall proteins with a common...
In many ascomycetous yeasts, the cell wall is composed of two main types of macromolecules: (a) polysaccharides, with a high content of β‐1,6‐ and β‐1,3‐linked glucan chains and minor amounts of chitin; and (b) cell wall proteins of different types. Synthesis and maintenance of these macromolecules respond to environmental changes, which are sensed by the cell wall integrity (CWI) signal transduction...
The glycosylphosphatidylinositol‐modified protein Rhd3/Pga29 of the human pathogen Candida albicans belongs to a family of cell wall proteins that are widespread among Candida species but are not found in other fungi. Pga29 is covalently linked to the β‐1,3‐glucan framework of the cell wall via β‐1,6‐glucan. It is a small and abundant O‐glycosylated protein and requires the protein‐O‐mannosyl transferase...
The cell walls of many ascomycetous yeasts consist of an internal network of stress-bearing polysaccharides, which serve as a scaffold for a dense external layer of glycoproteins. GPI-modified proteins are the most abundant cell wall proteins and often display a common organization. Their C-terminus can link them covalently to the polysaccharide network, they possess an internal serine- and threonine-rich...
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